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KMID : 0604520180440040389
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Journal of the Society of Cosmetic Scientists of Korea
2018 Volume.44 No. 4 p.389 ~ p.397
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Anti-aging Effect of Asterosaponin P1 Isolated from Asterina pectinifera
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Jin Moo-Hyun
Lee So-Young
Yeo Hye-Rin
Kim Hyo-Jin
Chang Yun-Hee
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Abstract
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The starfish, Asterina pectinifera Muller and Troschel (Asterinidae) is an indigenous species commonly found in all coasts of Korea causes damages to shellfish farms. In order to exterminate A. pectinifera, they are dried and used as fertilizer. Although various studies have been conducted to create high added value from the retrieved A. pectinifera, their actual utilization is relatively low. Accordingly, this study aimed to find new practical uses of starfish by identifying useful ingredients for skin anti-aging. Two polyhydroxysteroids and one asterosaponin were isolated from the A. pectinifera. The structures of these compounds were identified as 5α-cholestane-3β,6α,7α,8,15α,16β,26-heptol, 5α -cholestane-3β,4β,6α,7α,8,15β,16β,26-octol, and asterosaponin P1 on the basis of chemical and spectroscopic analysis. Among these compounds, we have found that asterosaponin P1 increased epidermal stem cell proliferation and the expression of hyaluronan synthase-2 and hyaluronan synthase-3 gene, which are enzymes that synthesize water-binding matrix hyaluronic acids in keratinocytes. In addition, asterosaponin P1 increased synthesis of pro-collagen type I, a major dermal collagen in fibroblasts. As a result, asterosaponin P1 isolated from A. pectinifera could be used as a useful cosmetic ingredient that improves skin symptoms accompanying skin aging.
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KEYWORD
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A. pectinifera, anti-aging, starfish, asterosaponin P1, polyhydroxysteroid
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